Impossible to really explain On Cinema IMO, but it's basically a movie review podcast / show hosted by fictional versions of Tim Heidecker and Gregg Turkington that's somehow overtime developed this insanely complicated world, complete with tv shows based on the review show, movies, bands, books, annual Oscar specials, and their own TV network.
Putting it in hutch terms, its like the Robert Pollard discography: impossible to really follow in depth unless you're an insane sicko
Lifeline???