indeed, both are awesome beer towns but i don't think that's a big factor for gigidub. if you want to do wine tourism, i believe that portland is the slightly better option since quality of wineries close to the city are better.
objectively, i might choose portland. it's (relatively) more exciting, "up and coming", edgy, etc. seattle is a little more settled, staid. that being said, seattle is bigger and will have more to offer in the way of arts, culture, sports, and other urban trappings. both are beautiful cities in beautiful settings.
subjectively, i would choose seattle because then you could come visit us. lots of great hiking right out our front door. fly fishing in the backyard. plenty of guest rooms. this is a real offer.