I saw QOTSA in San Francisco in October of 2003, it will forever go down as one of the best shows I've ever seen. The first 45 minutes felt like I was in a category 5 hurricane. The stoner crowd initially just watched slack-jawed, then by the end people were just going totaly mental.
Personally, I think what makes QOTSA appealing to me is the fact that they are basically a heavy band with an undercurrent of sexuality. The songs that rock hard always sway to some degree. I think Josh said once said that their music was "hard enough for the boys but sweet enough for the girls" or something to that effect. I am curious to see how they will be without Nick Oliveri, I've always loved some of his songs...he's the druggie punk rocker who screams as good as Husker Du-era Bob Mould or Frank Black.
When they played with Trail of Dead they were still breaking in Joey Castillo...the time with Dave Grohl on drums was probably a more impressive show.